Introducing OmneDiem Superzymes: A Full-Spectrum Digestive Enzyme with Betaine HCl

For educational purposes only. This article shares general information and is not medical advice. It is not a substitute for guidance from a qualified healthcare provider. Talk with your provider before starting any supplement, especially if you are pregnant or nursing, take medications, or manage a health condition.

From the OmneDiem team · New Products · About a 6-minute read

New from OmneDiem

OmneDiem Superzymes is a full-spectrum multi-enzyme formula that supports digestion from start to finish.† Each tablet combines betaine HCl, pepsin, pancreatin, ox bile extract, bromelain and papain to support the breakdown of proteins, fats and carbohydrates, and to help ease occasional gas, bloating and fullness after meals.† It comes in a 180-tablet bottle for $39.99, or $35.99 with Subscribe & Save.

What is OmneDiem Superzymes?

Superzymes is our first full-spectrum digestive enzyme. Most people know OmneDiem for our DAO enzymes, which support the breakdown of histamine from food.† Superzymes takes on a bigger job: supporting the digestion of the meal itself.

Product OmneDiem Superzymes Multi-Enzyme with Betaine HCl
Format 180 tablets
Key ingredients Betaine HCl, pepsin, pancreatin, ox bile extract, bromelain, papain
Supports Digestion of proteins, fats and carbohydrates; healthy stomach acid levels; nutrient absorption†
How to take At the start of meals, or as directed on the label; never on an empty stomach
Price $39.99, or $35.99 with Subscribe & Save (10% off)
Shipping Free in the US
Dietary note Contains animal-derived enzymes; not vegetarian or vegan
Made by OmneDiem, Ann Arbor, Michigan

Product details from omnediem.com, October 2026.

Why did OmneDiem create a full-spectrum digestive enzyme?

Think of a meal as a relay race. Stomach acid and pepsin run the first leg, bile hands off the fats, and pancreatic enzymes carry everything across the finish line. When one runner slows down, the whole race suffers, and food can move on only partly digested.

Stomach acid output can decline with age and with regular use of acid-reducing products. Yet many enzyme blends start at the second leg and skip the stomach entirely. We wanted one tablet that supports every leg of the race, so we built Superzymes around betaine HCl and pepsin, then added pancreatin, ox bile and plant enzymes.†

What are the benefits of Superzymes?

  • Supports complete digestion of proteins, fats and carbs†
  • Supports healthy stomach acid levels†
  • Helps ease occasional gas, bloating and fullness†
  • Supports absorption of calcium, B12, folate and iron†
  • Supports digestion of rich, fatty meals†

What ingredients are in Superzymes?

The six ingredients in Superzymes Six tiles. Betaine HCl: a mild form of hydrochloric acid that supports stomach acid levels. Pepsin: animal-derived, supports protein digestion in the stomach. Ox bile extract: animal-derived, helps emulsify fats. Pancreatin: animal-derived, enzymes for proteins, fats and carbohydrates. Bromelain: from pineapple, supports protein digestion. Papain: from papaya, supports protein digestion. Six ingredients, one tablet What each ingredient in Superzymes is there to do† Betaine HCl STOMACH · ACID Mild hydrochloric acid that supports healthy stomach acid levels† Pepsin STOMACH · ANIMAL The stomach's own protein enzyme† Ox bile extract FATS · ANIMAL Helps emulsify fats, preparing them for digestion† Pancreatin INTESTINE · ANIMAL Enzymes that break down proteins, fats and carbohydrates† Bromelain PROTEIN · PINEAPPLE Plant-based enzyme that supports protein digestion† Papain PROTEIN · PAPAYA Plant-based enzyme that supports protein digestion†

Who is Superzymes for?

Superzymes may be a good fit for:

  • Older adults, since stomach acid output can decline with age
  • People who eat protein-rich or high-fat meals
  • Anyone who feels heavy or uncomfortable after eating†

How is Superzymes different from OmneDiem's DAO enzymes?

They do different jobs. Superzymes supports the digestion of proteins, fats and carbohydrates. Our DAO enzymes support the breakdown of histamine from food.†

  Superzymes Histamine Digest (DAO)
Main job Supports digestion of proteins, fats and carbs† Supports breakdown of dietary histamine†
Key ingredients Betaine HCl, pepsin, pancreatin, ox bile, bromelain, papain DAO enzyme, 30,000 HDU per capsule
May fit if Heavy or rich meals leave you full, gassy or sluggish Reactions follow aged cheese, wine, leftovers or fermented foods
Learn more Shop Superzymes Shop Histamine Digest

Thinking about using both? Talk with your healthcare provider before combining supplements.

How do I take Superzymes?

Take Superzymes at the start of meals, or as directed on the label. Do not take it on an empty stomach. Many people start with their heaviest meal of the day.

Who should not take Superzymes?

Because Superzymes contains betaine HCl, do not use it if you have a history of ulcers, or if you take NSAIDs, steroids or acid-reducing medications, without first talking with your healthcare provider.

Superzymes contains animal-derived enzymes, so it is not suitable for vegetarians or vegans.

Where can I buy Superzymes, and how much does it cost?

Superzymes is available now at omnediem.com. A 180-tablet bottle is $39.99, about 22 cents a tablet. With Subscribe & Save, it is $35.99, about 20 cents a tablet, and shipping is free in the US.

Digestion, start to finish

OmneDiem Superzymes Multi-Enzyme with Betaine HCl · 180 tablets

Subscribe & Save 10% · Free US shipping

Shop Superzymes

What else do people ask about Superzymes?

What is OmneDiem Superzymes?

Superzymes is a full-spectrum multi-enzyme formula with betaine HCl, pepsin, pancreatin, ox bile, bromelain and papain that supports digestion of proteins, fats and carbs.†

What is betaine HCl?

Betaine HCl is a mild form of hydrochloric acid that supports stomach acidity and the beginning of protein digestion.†

Can Superzymes help with bloating?

By supporting thorough digestion, Superzymes helps ease occasional gas, bloating and that heavy feeling after meals.†

When should I take Superzymes?

Take it at the start of meals, or as directed on the label. Do not take it on an empty stomach.

Is Superzymes vegetarian?

No. Superzymes contains animal-derived pepsin, pancreatin and ox bile extract, along with plant-derived bromelain and papain.

How much does Superzymes cost?

A 180-tablet bottle is $39.99 on omnediem.com, or $35.99 with Subscribe & Save. Shipping is free in the US.

Scientific references

  1. Ianiro G, Pecere S, Giorgio V, Gasbarrini A, Cammarota G. Digestive enzyme supplementation in gastrointestinal diseases. Curr Drug Metab. 2016;17(2):187-193.
  2. Yago MR, et al. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Mol Pharm. 2013;10(11):4032-4037.
  3. Roxas M. The role of enzyme supplementation in digestive disorders. Altern Med Rev. 2008;13(4):307-314.

†These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Prices are from omnediem.com as of October 2026 and are subject to change.

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