Histamine Digest with DAO Enzymes

OmneDiem® Histamine Digest® supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking OmneDiem® Histamine Digest® prior to consuming high-histamine foods and beverages helps defend against digestive histamine sensitivity and the occurrence of accompanying reactions.* Histamine Intolerance is real. OmneDiem® Histamine Digest® can help. 

  • Natural: Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine.
  • Convenient: DAO promotes histamine degradation within 20 min after intake.
  • Safe: DAO is not absorbed into the body, and no adverse events have been recorded with DAO supplementation.

Symptoms of Histamine Intolerance

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated, and are widespread. Common reactions include:

  • Vasodilation (flushing/reddening)
  • Hypotension/Tachycardia
  • Stuffy, Runny Nose/Sneezing
  • Swelling or Red, Watery Eyes
  • Diarrhea, Cramps, Bloating
  • Feelings of Anxiety
  • Urticaria (hives)

Prevalence

Indication Percentage of Western Population
Lactose Intolerance 10-30%
Fructose Malabsorption 33%
Food Allergy 3-5%
Histamine Intolerance 2-5%
Celiac Disease 0.5%
Fructose Intolerance <.01%

What is Histamine?

Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages.

OmneDiem® Histamine Digest® supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking OmneDiem® Histamine Digest® prior to consuming high-histamine foods and beverages helps defend against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance.*

Allergy or Intolerance?

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme.

  • Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure.
  • Intolerance – A reaction that does not involve an immunological response. Reactions can take time to appear and increase with the level of exposure.
    • Supplement with Digestive Enzyme: Diamine Oxidase (DAO)* that helps neutralizes histamine in the gut*

Histamine intolerance occurs when histamine levels in the body become too high or cannot be properly broken down, exceeding the amount of diamine oxidase (DAO) available for degradation.

How Histamine Digest Works

Diamine Oxidase (DAO) is responsible for the degradation of biogenic amines ingested with food (dietary histamine). DAO is active in the ileum and jejunum of the small intestine. It is also found concentrated in the kidney, thymus and placenta. When histamine levels in the digestive tract become excessive, DAO breaks down the excess. When there is a deficiency of available DAO or DAO activity is blocked, reactions can occur. OmneDiem Histamine Digest supplies natural, active supplemental DAO to help neutralize excess histamine.* •Non-systemic, no drug — nutrient interactions, natural porcine kidney extract.

Causes of Histamine Intolerance

Imbalance between histamine and the degrading enzyme Diamine Oxidase (DAO)

Histamine-Rich Foods

  • Chocolate
  • Cheese (all types, especially aged)
  • Sauerkraut
  • Tuna
  • Aged, cured, processed, and fermented meats (pepperoni, sausage, bacon)
  • Tomatoes/Ketchup
  • Vinegar (all types)
  • Alcoholic beverages
  • Shellfish
  • Avocado
  • Bananas
  • Eggplant