Histamine Intolerance is real. OmneDiem® Histamine Digest can help.
OmneDiem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking OmneDiem Histamine Digest prior to consuming high histamine foods and beverages helps defend against digestive histamine sensitivity and the occurrence of accompanying reactions.*
Natural
Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine.
Convenient
DAO promotes histamine degradation within 20 min after intake.
Safe
DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation.
What is Histamine?
Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages.
OmneDiem® Histamine Digest supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking OmneDiem® Histamine Digest prior to consuming high histamine foods and beverages helps defend against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance.*
Allergy or Intolerance?
While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme.
Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure.
Intolerance – A reaction that does not involve an immunological response. Reactions can take time to appear and increase upon level of exposure.
Symptoms of Histamine Intolerance
While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated and are widespread. Common reactions include:
- Vasodilation (flushing/reddening)
- Hypotension/Tachycardia
- Stuffy, Runny Nose/Sneezing
- Swelling or Red, Watery Eyes
- Headache or Migraine
- Diarrhea, Cramps, Bloating
- Feelings of Anxiety
- Urticaria (hives)
Prevalence
| Indication | Percentage of Western Population |
| Lactose Intolerance | 10-30% |
| Fructose Malabsorption | 33% |
| Food Allergy | 3-5% |
| Histamine Intolerance | 2-5% |
| Celiac Disease | 0.5% |
| Fructose Intolerance | <.01% |
Solution - Digestive Enzyme: Diamine Oxidase (DAO)*
• Neutralizes histamine in the gut*
• Non-systemic, no drug — nutrient interactions, natural kidney extract
8% of people worldwide are affected by histamine intolerance†
Intolerance occurs when the histamine levels in the body get too high or can’t be broken down properly — when histamine levels exceed the amount of diamine oxidase enzyme (DAO) available for degradation.
Causes of Histamine Intolerance
Imbalance between histamine and the degrading enzyme Diamine Oxidase (DAO)
Histamine-Rich Foods
- Chocolate
- Cheese (all types, especially aged)
- Sauerkraut
- Tuna
- Aged, cured, processed and fermented meats (pepperoni, sausage, bacon)
- Tomatoes/Ketchup
- Vinegar (all types)
- Alcoholic beverages
- Shellfish
- Avocado
- Bananas
- Eggplant
Histamine Liberators
- Berries (especially strawberries)
- Alcoholic Beverages
- Milk and dairy products
- Citrus fruits
- Bananas
- Chocolate
- Shellfish
DAO Enzyme-Inhibiting Drugs
- Acemetacin
- Acetylcysteine
- Adalimumab (Humaira)
- Amitriptyline
- Antihistamines
- Aspirin
- Diazapam
- Duloxetine (Cymbalta)
- Etanercept (Enbrel)
- Fluoxetine (Prozac)
- Haloperidol
- Ibuprofen
- Neomycin
- Propranolol
- Sertraline (Zoloft)
- Venlafaxine
- Verapamil
Triple-threat
Alcoholic beverages present a “triple-threat” to histamine levels by:
- 1. Introducing excess histamine levels
- 2. Liberating histamine
- 3. Blocking the activity of DAO in the gastrointestinal tract.
DOES NOT CONTAIN: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.
Ambrosha Ossorio (verified owner) –
I have a rare disease called indolent systemic Mastocytosis and my GI was in BAD shape. But I started taking this and it’s unbelievable what has happened. I can eat again, I dont have stomach issues . I LOVE this product. Love love love !!!
Eileen Folan (verified owner) –
Diagnosed recently with Histamine Intolerance, on top of several lifelong food allergies, both of which severely limit my diet. Histamine Digest has made an incredible difference in the variety of foods that I am now able to eat. I am very grateful to have found it!
Tracy Tigue –
Through the site I purchased Histamine Digest. The price is high but the product is great! I use it without any problems. And the product arrived in the shortest possible time. Recommend!
C Nilles –
Wish I had found this sooner. Taken once every morning has almost completely eliminated my histamine allergies. I’ve got my life back again!
NORVIN GRINER (verified owner) –
I have been a satisfied customer of OmneDiem for several years. My food related histamine issues came out of nowhere back in 2016 (intense allergies). After doing extensive research I found this company and their “magic” enzyme. For me, it was a game changer. I no longer fear eating high histamine foods. I take one to three caps prior to a meal depending on the food’s histamine levels. Customer Service is outstanding as well. Big thanks!
N. Griner
San Juan/Palm Springs
Maddy (verified owner) –
I have a double mutation on AOC1 gene which makes diamine oxidase. Yet I am lucky, usually only get triggered w migraine from wine. Play with dosage. To enjoy a nice glass of red wine with no headache at all, zero, I need 3 capsules and wait 10 minutes before start the wine. But it works. No doubt about that. 23andme can tell you if you have this defect. Lots of people with migraine do.
Rod Simmons (verified owner) –
Recently I learned I may be histamine intolerant and may have been for 18 years. I’m still learning about HIT but it appears DAO prevents the buildup of histamine in the gut which can occur after several days depending on histamine levels in foods, high protein diet, alcohol, DAO levels and other factors. Some histamine is necessary BUT too much is a huge problem.
So as I understand it, this product is licensed from the original patent holder for DAO, Stada. I ordered the product and have tried it now for 2 months. It does appear to have great therapeutic value as I saw a significant improvement in my symptoms. However, I wasn’t always disciplined (take 10min before each meal, eg) so it’s possible it could even be better. Moreover, when I didn’t take Hist Digest for several days and I consumed a high protein diet, my symptoms returned with vengeance.
I’m currently out of stock so I’ve re-ordered and look forward to updating others on my progress!
fadi nuaman (verified owner) –
I was diagnosed with histamine intolerance at my 19th birthday and had sever IBD! I could not eat for 2 years with out getting a flare up! This amazing product saved my life today I live a normal life thanks to these amazing people who came up with this product.
Sure it’s expensive and I have to work an extra shift a week to be able to afford it but it’s so worth it to be able to live again!
I eat four meals a day as long I take a capsule with each meal It does work for me.
So grateful!!!