Welcome to OmneDiem. You may have noticed our URL changed from diemnutrition.com to omnediem.com, but fear not, you are still in the right place.

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Histamine Digest 120
OmneDiem Histamine Digest Supplement Facts
OmneDiem Histamine Digest label
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Home Shop All Products Histamine Digest with DAO 120 Capsules
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Histamine Digest with DAO 60 Capsules $54.95 — or subscribe and save 5%
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Histamine Digest with DAO 120 Capsules

Rated 4.75 out of 5 based on 8 customer ratings
(8 customer reviews)

$87.95 — or subscribe and save 5%

OmneDiem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking OmneDiem Histamine Digest prior to consuming high histamine foods and beverages helps defend against digestive histamine sensitivity and the occurrence of accompanying reactions.*

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1 - 2 — $87.95
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7+ 15 % $74.76

The longer you stay subscribed the more you save.

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1 - 2 — $83.55
3 - 6 10 % $75.20
7+ 15 % $71.02

The longer you stay subscribed the more you save.

Subscriptions Delivered Discount (%) Price
1 - 2 — $83.55
3 - 6 10 % $75.20
7+ 15 % $71.02

The longer you stay subscribed the more you save.

Subscriptions Delivered Discount (%) Price
1 - 2 — $83.55
3 - 6 10 % $75.20
7+ 15 % $71.02
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SKU: DAO120 Categories: All Products, Food Intolerance
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Description
Histamine Digest feast

Histamine Intolerance is real. OmneDiem® Histamine Digest can help. 

OmneDiem Histamine Digest supplies Diamine Oxidase (DAO), the enzyme that neutralizes histamine in the digestive tract.* Taking OmneDiem Histamine Digest prior to consuming high histamine foods and beverages helps defend against digestive histamine sensitivity and the occurrence of accompanying reactions.*

Natural

Our DAO is a natural enzyme-rich protein extract from porcine kidney that is delivered to the small intestine.

Convenient

DAO promotes histamine degradation within 20 min after intake.

Safe

DAO is not absorbed into the body and no adverse events have been recorded with DAO supplementation.

What is Histamine?

Histamine is a biogenic amine present in our bodies and in our food supply. Biogenic amines are found in everything from dairy products and meats to fruits, vegetables and grains. Processes that result in the microbial alteration of foods — such as aging (meat), fermentation (wine, spirits, cheese), and package processing (prepared packed foods) — can increase the levels of histamine and other biogenic amines in foods and beverages.

OmneDiem® Histamine Digest supplies Diamine Oxidase, the enzyme that neutralizes dietary histamine in the digestive tract. Taking OmneDiem® Histamine Digest prior to consuming high histamine foods and beverages helps defend against digestive histamine sensitivity to help reduce the occurrence of histamine intolerance.*

Histamine

Allergy or Intolerance?

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme.

Allergy – An immune system response to a specific allergenic substance. Symptoms can appear quickly with very little exposure.

Intolerance – A reaction that does not involve an immunological response. Reactions can take time to appear and increase upon level of exposure.

Allergy vs Intolerance

Symptoms of Histamine Intolerance

While the symptoms of Histamine Intolerance (HIT) may mimic allergic reactions, HIT is not a classical food allergy. Rather, research suggests that HIT is mediated by a deficiency in levels and/or activity of the Diamine Oxidase enzyme. Reactions are variable, seem unrelated and are widespread. Common reactions include:

  • Vasodilation (flushing/reddening)
  • Hypotension/Tachycardia
  • Stuffy, Runny Nose/Sneezing
  • Swelling or Red, Watery Eyes
  • Headache or Migraine
  • Diarrhea, Cramps, Bloating
  • Feelings of Anxiety
  • Urticaria (hives)

Prevalence

Indication Percentage of Western Population
Lactose Intolerance 10-30%
Fructose Malabsorption 33%
Food Allergy 3-5%
Histamine Intolerance 2-5%
Celiac Disease 0.5%
Fructose Intolerance <.01%

Solution - Digestive Enzyme: Diamine Oxidase (DAO)*

• Neutralizes histamine in the gut*

• Non-systemic, no drug — nutrient interactions, natural kidney extract

8% of people worldwide are affected by histamine intolerance†

Intolerance occurs when the histamine levels in the body get too high or can’t be broken down properly — when histamine levels exceed the amount of diamine oxidase enzyme (DAO) available for degradation.

How Histamine Digest Works

Diamine Oxidase (DAO) is responsible for the degredation of biogenic amines ingested with food (dietary histamine). DAO is active in the ileum and jejunum of the small intestine. It is also found concentrated in the kidney, thymus and placenta. When histamine levels in the digestive tract become excessive, DAO breaks down the excess. When there is a deficiency of available DAO or DAO activity is blocked, reactions can occur. OmneDiem Histamine Digest supplies natural, active supplemental DAO to help neutralize excess histamine.*

Causes of Histamine Intolerance

Imbalance between histamine and the degrading enzyme Diamine Oxidase (DAO)

Cause of histamine intolerance
Histamine Digest

Histamine-Rich Foods

  • Chocolate
  • Cheese (all types, especially aged)
  • Sauerkraut
  • Tuna
  • Aged, cured, processed and fermented meats (pepperoni, sausage, bacon)
  • Tomatoes/Ketchup
  • Vinegar (all types)
  • Alcoholic beverages
  • Shellfish
  • Avocado
  • Bananas
  • Eggplant
Histamine Beer

Histamine Liberators

  • Berries (especially strawberries)
  • Alcoholic Beverages
  • Milk and dairy products
  • Citrus fruits
  • Bananas
  • Chocolate
  • Shellfish
Medication

DAO Enzyme-Inhibiting Drugs

  • Acemetacin
  • Acetylcysteine
  • Adalimumab (Humaira)
  • Amitriptyline
  • Antihistamines
  • Aspirin
  • Diazapam
  • Duloxetine (Cymbalta)
  • Etanercept (Enbrel)
  • Fluoxetine (Prozac)
  • Haloperidol
  • Ibuprofen
  • Neomycin
  • Propranolol
  • Sertraline (Zoloft)
  • Venlafaxine
  • Verapamil

Triple-threat

Alcoholic beverages present a “triple-threat” to histamine levels by: 

  1. 1. Introducing excess histamine levels
  2. 2. Liberating histamine 
  3. 3. Blocking the activity of DAO in the gastrointestinal tract.

DOES NOT CONTAIN: Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.

 *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

Additional information
Weight 3.1 oz
Dimensions 2.25 × 2.25 × 4 in
Reviews (8)

8 reviews for Histamine Digest with DAO 120 Capsules

  1. Rated 5 out of 5

    Ambrosha Ossorio (verified owner) – January 7, 2021

    I have a rare disease called indolent systemic Mastocytosis and my GI was in BAD shape. But I started taking this and it’s unbelievable what has happened. I can eat again, I dont have stomach issues . I LOVE this product. Love love love !!!

  2. Rated 5 out of 5

    Eileen Folan (verified owner) – June 16, 2021

    Diagnosed recently with Histamine Intolerance, on top of several lifelong food allergies, both of which severely limit my diet. Histamine Digest has made an incredible difference in the variety of foods that I am now able to eat. I am very grateful to have found it!

  3. Rated 4 out of 5

    Tracy Tigue – July 9, 2021

    Through the site I purchased Histamine Digest. The price is high but the product is great! I use it without any problems. And the product arrived in the shortest possible time. Recommend!

  4. Rated 5 out of 5

    C Nilles – July 18, 2021

    Wish I had found this sooner. Taken once every morning has almost completely eliminated my histamine allergies. I’ve got my life back again!

  5. Rated 5 out of 5

    NORVIN GRINER (verified owner) – July 28, 2021

    I have been a satisfied customer of OmneDiem for several years. My food related histamine issues came out of nowhere back in 2016 (intense allergies). After doing extensive research I found this company and their “magic” enzyme. For me, it was a game changer. I no longer fear eating high histamine foods. I take one to three caps prior to a meal depending on the food’s histamine levels. Customer Service is outstanding as well. Big thanks!
    N. Griner
    San Juan/Palm Springs

  6. Rated 5 out of 5

    Maddy (verified owner) – December 9, 2021

    I have a double mutation on AOC1 gene which makes diamine oxidase. Yet I am lucky, usually only get triggered w migraine from wine. Play with dosage. To enjoy a nice glass of red wine with no headache at all, zero, I need 3 capsules and wait 10 minutes before start the wine. But it works. No doubt about that. 23andme can tell you if you have this defect. Lots of people with migraine do.

  7. Rated 4 out of 5

    Rod Simmons (verified owner) – April 26, 2022

    Recently I learned I may be histamine intolerant and may have been for 18 years. I’m still learning about HIT but it appears DAO prevents the buildup of histamine in the gut which can occur after several days depending on histamine levels in foods, high protein diet, alcohol, DAO levels and other factors. Some histamine is necessary BUT too much is a huge problem.

    So as I understand it, this product is licensed from the original patent holder for DAO, Stada. I ordered the product and have tried it now for 2 months. It does appear to have great therapeutic value as I saw a significant improvement in my symptoms. However, I wasn’t always disciplined (take 10min before each meal, eg) so it’s possible it could even be better. Moreover, when I didn’t take Hist Digest for several days and I consumed a high protein diet, my symptoms returned with vengeance.

    I’m currently out of stock so I’ve re-ordered and look forward to updating others on my progress!

  8. Rated 5 out of 5

    fadi nuaman (verified owner) – November 14, 2022

    I was diagnosed with histamine intolerance at my 19th birthday and had sever IBD! I could not eat for 2 years with out getting a flare up! This amazing product saved my life today I live a normal life thanks to these amazing people who came up with this product.

    Sure it’s expensive and I have to work an extra shift a week to be able to afford it but it’s so worth it to be able to live again!

    I eat four meals a day as long I take a capsule with each meal It does work for me.
    So grateful!!!

Only logged in customers who have purchased this product may leave a review.

Shipping & Delivery

We are dedicated to making sure your experience ordering from Diem Direct is always great. Below are the shipping methods we offer, so you can choose which is right for you and know when to expect your order. 

United States shipping methods and delivery ETAs: 

  • Standard shipping (via USPS): 7 business days after the item ships.
  • UPS Ground shipping: 3-5 business days after the item ships.
  • UPS Next Day/2nd Day Air: guaranteed same day shipment if your order is placed on a business day by 11am, Central Standard Time; all Air orders entered after this time will ship the next business day.
  • Your order will generally be shipped the same day if your order is placed by 11am, Central Standard Time. If your order is placed after that time, or on a non-business day, your order will ship the next business day. No C.O.D. will be accepted.
  • Business Days are defined as Monday through Friday.

International shipping methods and delivery ETAs: 

  • UPS Worldwide Expedited: 7-10 business days after the item ships.
  • USPS First Class International (North America only): up to 20 business days after the item ships.
  • Your order will generally be shipped the same day if your is placed by 11am Central Standard Time. If your order is placed after that time, or on a non-business day, your order will ship the next business day. No C.O.D. will be accepted.
  • Delivery time frames do not include any time the package may be in possession by your local Customs bureau, only the time in transit by the carrier.
  • Business Days are defined as Monday through Friday.

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Diem Direct Supplements to Seize The Day

221 Dino Drive, Ann Arbor, MI 48103
customerservice@omnediem.com
Customer Service: (888) 876-5765

Customer Service Hours:
Monday – Friday 9am-5pm EST.

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*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any diseases.

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