Why doesn’t OmneDiem offer a pea-derived DAO?
OmneDiem has over 20 years of experience in the world of Diamine Oxidase enzymes. The original inventor of the DAO enzyme solution is part of the OmneDiem Team. Given this long, strong history, OmneDiem has determined that creating a pea-derived DAO for commercial sale is not feasible. This is primarily due to significant manufacturing challenges including scalability, cost-effectiveness, and enzymatic stability and activity.
Porcine kidneys are a readily available and concentrated source of DAO from an existing food supply chain. Pea-derived DAO requires farming, lots of water, pesticide treatment and a complex and less-established process of germinating peas, extracting the enzyme, and ensuring its stability through drying and formulation. This process is far more difficult to standardize and scale for mass production, making it less commercially viable compared to the well-understood and stable porcine source. In addition, the lack of clinical supporting evidence for safety and efficacy, the need to register as a New Dietary Ingredient (NDI), and potential allergenic concerns presents many challenges to overcome with pea-derived DAO. To our current knowledge, these challenges are not currently being met by any pea-derived DAO manufacturer.