Enjoy the Night & Feel Better Tomorrow. Neutralize Histamine in Fermented Beverages*
Histamine Neutralizing Enzyme — Diamine Oxidase (DAO)*
Drink HD: The DAO Enzyme Supplement for Alcohol‑Histamine Reactions*
Enjoy the night. Feel better tomorrow. Drink HD delivers diamine oxidase (DAO) — the same enzyme your body naturally uses to break down histamine in the gut — so you can stay comfortable while enjoying wine, craft beer, and spirits.*
90 designed‑release capsules · Made in a GMP‑certified U.S. facility
What Is Drink HD?
Drink HD is a dietary supplement from OmneDiem® that provides diamine oxidase (DAO), the primary enzyme responsible for breaking down histamine from food and drink in the digestive tract.* Fermented alcoholic beverages — especially red wine, craft beer, and aged spirits — naturally contain histamine, and alcohol can slow your body's own DAO activity. Drink HD supplements that enzyme right where it works: the gut.*
Do You React to Wine, Beer, or Spirits?
Many adults notice these common alcohol‑histamine reactions — often starting in their 30s and 40s as the body's natural DAO production declines:
- Flushed, red face, chest & neck
- Sneezing
- Congestion / stuffy nose
- Digestive discomfort
If red wine no longer loves you back, if craft beers feel a little too crafty in your belly, or if a snort of whisky makes you sneeze — Drink HD was made for you.*
How Does Drink HD Work?
- Take 1–2 capsules prior to or upon consuming any alcoholic beverage — especially high‑histamine wines, craft beers, and aged spirits.
- Designed‑release capsules carry the DAO enzyme past the stomach and release it in the gut, where dietary histamine is absorbed.
- DAO breaks down histamine from your drink, supporting your body's natural histamine metabolism so you can stay comfortable.*
Drink HD features the DAO2® blend (porcine kidney extract providing naturally sourced diamine oxidase). It works with your body's own process — it won't interfere with your enjoyment of your beverage.*
Stock Up Before Your Next Night Out
The 90‑count bottle is our best value — enough DAO support for months of dinners, tastings, and celebrations. Keep it home; keep the travel tube in your bag.
Buy the 90‑Count Bottle →
Drink HD is a dietary supplement. It does not reduce blood alcohol levels or impairment. Please drink responsibly. Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition.
Choose Your Drink HD
Drink HD — 90‑Count Refill Bottle
- 90 delayed‑release DAO capsules
- 45–90 servings per bottle
- Lowest cost per capsule
- Best for regular enjoyment at home
Drink HD — 20‑Count Travel Tube
- 20 delayed‑release DAO capsules
- Pocket‑size tube for nights out & travel
- Great first try
From the OmneDiem Blog
What Alcohol Is Highest in Histamine?
Red wine, aged champagne, and dark beer top the histamine charts — while vodka, gin, and blanco tequila barely register. See the full drink‑by‑drink ranking, learn why wine hits harder during allergy season, and find out whether sulfites or histamine are really to blame for your wine headaches.
Read the Full Ranking →Why Choose OmneDiem?
OmneDiem® is the maker of Histamine Digest®, a leading DAO enzyme supplement line. Drink HD is produced in a GMP‑certified U.S. facility for consistent quality, safety, and potency, and uses designed‑release capsules with no sugar, dairy, gluten, or artificial additives.
Frequently Asked Questions
What does Drink HD do?
Drink HD provides diamine oxidase (DAO), the enzyme that breaks down histamine from food and beverages in the gut. Taken before drinking, it supports your body's natural ability to process the histamine found in fermented alcoholic beverages like red wine, craft beer, and aged spirits.*
When should I take Drink HD?
Take one to two capsules prior to or upon consuming any alcoholic beverage — especially high‑histamine drinks such as red wine, craft beers, and aged spirits.
Is Drink HD a hangover cure?
No. Drink HD is not a hangover remedy and does not affect blood alcohol levels or impairment. It is a dietary supplement that supplies the DAO enzyme to help break down histamine — one specific compound found in fermented drinks.* Always drink responsibly.
Why does red wine bother me more than other drinks?
Fermented and aged beverages are among the highest‑histamine drinks, and red wine typically tops the list. Alcohol also liberates histamine in the gut and can slow your body's own DAO enzyme — a double effect that becomes more noticeable with age, as natural DAO production declines.
What's the difference between the 90‑count bottle and the 20‑count tube?
Same formula, different sizes. The 90‑count bottle is the best value per capsule and is ideal for keeping at home; the 20‑count tube fits in a pocket or purse for nights out and travel. Most customers start with the tube and restock with the 90‑count bottle.
What is Drink HD made from?
Each designed‑release capsule contains the DAO2® blend — a porcine kidney extract that naturally provides the diamine oxidase enzyme. It contains no sugar, dairy, gluten, or artificial additives and is made in a GMP‑certified U.S. facility.
Can I take Drink HD with high‑histamine foods too?
Drink HD's DAO enzyme works on histamine from both food and drink in the digestive tract.* For everyday meal support or extra histamine intolerance help, see OmneDiem's full DAO Enzyme Supplements collection, including the Histamine Digest® line.
Your New Drinking Buddy Is Waiting
Don't let histamine crash the party. Get the 90‑count bottle of Drink HD and be ready for every toast, tasting, and celebration.*
Shop Drink HD 90‑Count →Drink HD is a dietary supplement. It does not reduce blood alcohol levels or impairment. Please drink responsibly. Consult your healthcare provider before use if you are pregnant, nursing, taking medication, or have a medical condition.