Connective Tissue TLC
Joint & Connective Tissue Support
Introducing OmneDiem’s Connective Tissue TLC
Three clinically studied ingredients — TENDOFORTE®, TENDAXION®, and CHONDROPURE®5,6 — in one formula built for the tendons, ligaments, and cartilage that keep active bodies moving.*
The quick answer
Connective Tissue TLC (Tendons, Ligaments & Cartilage) is an OmneDiem dietary supplement that combines three branded, clinically studied ingredients to nourish connective tissue — whether you train hard, move for a living, or simply want to keep doing the things you love.*
- TENDOFORTE® bioactive collagen peptides for tendon and ligament strength*
- TENDAXION® mucopolysaccharides, collagen type I & vitamin C for tendon resilience*
- CHONDROPURE® US-made chondroitin sulfate to nourish cartilage*
In this article
Why connective tissue deserves its own support
Muscles get the spotlight, but tendons, ligaments, and cartilage do much of the quiet work. Tendons transfer force from muscle to bone. Ligaments hold joints steady. Cartilage cushions every step, squat, and stride.
Here’s the catch: connective tissue has a far smaller blood supply than muscle, so it adapts and recovers more slowly. Think of muscle as a busy highway with constant deliveries, and connective tissue as a country road where supplies arrive less often. When training ramps up — or the years add up — that slower supply line can become the limiting factor.
Strong muscles can only perform as well as the tendons, ligaments, and cartilage that carry the load.
Connective Tissue TLC was designed to deliver targeted building blocks to exactly those tissues, rather than relying on generic collagen alone.*
Give your connective tissue some TLC
TENDOFORTE® + TENDAXION® + CHONDROPURE® in one daily formula.*
Shop Connective Tissue TLC$68.50What’s inside Connective Tissue TLC
Each ingredient was chosen for a specific job. Together they address connective tissue from three angles: strength, resilience, and cartilage nutrition.*
Three ingredients. Three targets.
Each Connective Tissue TLC ingredient has a primary target. MPS = mucopolysaccharides.
Tendon & ligament strength
TENDOFORTE® bioactive collagen peptides
TENDOFORTE® is a specific set of bioactive collagen peptides developed by GELITA to support the tendons and ligaments. Rather than acting as generic protein, these peptides are designed to signal connective-tissue cells to build extracellular matrix — the scaffolding that gives tendons and ligaments their strength.* See the TENDOFORTE® clinical research.
Findings are from studies of the TENDOFORTE® ingredient as reported by GELITA; study doses and protocols may differ from a single serving of Connective Tissue TLC. Individual results vary.
Tendon resilience
TENDAXION® mucopolysaccharides, collagen type I & vitamin C
TENDAXION® is a proprietary combination of three nutrients tendons rely on: mucopolysaccharides (the gel-like compounds that help tissue hold water and stay supple), collagen type I (the main structural protein in tendons), and vitamin C, which the body needs to form collagen.*
Developed by Bioiberica, TENDAXION® has been evaluated across multiple scientific studies. That research indicates it helps maintain the tendons’ biomechanical properties, and its use was associated with a faster return to training when combined with physical therapy.4*
TENDAXION® is intended to complement — not replace — a rehab or physical therapy program. Follow your provider’s guidance.
Cartilage nourishment
CHONDROPURE® US-made chondroitin sulfate
Chondroitin sulfate is a natural building block of the body’s extracellular matrix. It’s found in cartilage, tendons, ligaments, skin, and blood vessels, and it is the main repeating unit of the compounds that give cartilage its water-holding, shock-absorbing structure.5 CHONDROPURE® is a US-made chondroitin sulfate that helps nourish cartilage and other connective tissues.*
Why this matters for active people: cartilage isn’t inert padding — it responds to how you move. In a 2021 study of 17 recreational marathon runners, a single race measurably shifted cartilage activity: blood levels of hyaluronic acid (a key joint-lubricating compound) rose roughly four-fold right after the race, and a marker of new type II collagen formation stayed elevated for 48 hours.6 In other words, cartilage works hard under load and keeps working afterward — and it needs raw materials to do that work.
Honest evidence note: The marathon study measured how cartilage responds to running; it did not test a supplement. The 2009 chondroitin review summarizes laboratory and early human research, and several of its authors worked for a chondroitin manufacturer. Human research on chondroitin overall is mixed, so we view CHONDROPURE® as one part of a complete approach that includes training, rest, and good nutrition.
Who Connective Tissue TLC is for
- Athletes and gym-goers who want their tendons and ligaments to keep pace with their muscles*
- Runners, hikers, and weekend warriors putting repeated load on knees, ankles, and hips*
- Active adults 40+, including women in perimenopause and beyond, who want to keep moving comfortably*
- Anyone returning to training under a provider’s or physical therapist’s guidance*
Consult your healthcare provider before starting any supplement, especially if you are pregnant, nursing, taking medication, or managing a health condition.
Ready to support the tissues that keep you moving?
Three clinically studied ingredients. One formula for tendons, ligaments & cartilage.*
Shop Now$68.50Frequently asked questions
What is Connective Tissue TLC?
Connective Tissue TLC is an OmneDiem dietary supplement for tendons, ligaments, and cartilage. It combines TENDOFORTE® bioactive collagen peptides, TENDAXION® (mucopolysaccharides, collagen type I, and vitamin C), and CHONDROPURE® US-made chondroitin sulfate.*
How is it different from a regular collagen supplement?
Most collagen powders are general-purpose protein. Connective Tissue TLC uses ingredients studied specifically for connective tissue: bioactive peptides researched for tendons and ligaments, a tendon-focused nutrient complex, and chondroitin sulfate for cartilage.*
What does TENDOFORTE® do?
TENDOFORTE® bioactive collagen peptides are designed to support tendon and ligament strength. In GELITA-reported research, use alongside training was associated with an 11% increase in patellar tendon cross-sectional area in healthy active men, improved ankle stability in active adults, and a faster return to running.*
What is chondroitin sulfate and why is it in this formula?
Chondroitin sulfate is a natural component of cartilage, tendons, and ligaments that helps cartilage hold water and absorb impact. CHONDROPURE® provides US-made chondroitin sulfate to help nourish cartilage.* Human research on chondroitin is mixed, which is why it’s paired with the other two ingredients rather than used alone.
Can Connective Tissue TLC help me get back to training?
In clinical research, TENDOFORTE® and TENDAXION® were associated with a faster return to training — TENDAXION® specifically when combined with physical therapy.* Connective Tissue TLC is not a substitute for medical evaluation or rehab; follow your provider’s guidance.
Can I take it with OmneDiem Joint Comfort?
The two formulas are complementary: Joint Comfort (ZOARA® complex with hyaluronic acid, type II collagen, and turmeric) focuses on the joint itself, while Connective Tissue TLC focuses on tendons, ligaments, and cartilage.* Check with your healthcare provider before combining supplements.
Related resources
Pamela Sloop, FNP-C, is an OmneDiem affiliate partner.
References
- Jerger S, et al. (2022, 2023). Studies of TENDOFORTE® bioactive collagen peptides and tendon adaptation in healthy active men aged 18–40. As summarized by GELITA.
- Dressler P, et al. (2018). TENDOFORTE® and ankle stability in 50 active men and women; 3-month supplementation with 3-month follow-up. As summarized by GELITA.
- Praet S, et al. (2019). TENDOFORTE® and return to running in male and female runners, average age 43. As summarized by GELITA.
- Bioiberica. TENDAXION® ingredient research summary. bioiberica.com
- du Souich P, García AG, Vergés J, Montell E. Immunomodulatory and anti-inflammatory effects of chondroitin sulphate. J Cell Mol Med. 2009;13(8A):1451–1463. doi:10.1111/j.1582-4934.2009.00826.x
- Hernández-Hermoso JA, Nescolarde L, Roca E, et al. Marathon running increases synthesis and decreases catabolism of joint cartilage type II collagen accompanied by high-energy demands and an inflammatory reaction. Front Physiol. 2021;12:722718. doi:10.3389/fphys.2021.722718
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Statements about TENDOFORTE®, TENDAXION®, and CHONDROPURE® refer to research on these branded ingredients or their ingredient class; individual results may vary. This article is for educational purposes only and is not a substitute for professional medical advice. Consult a qualified healthcare provider before beginning any new supplement, especially if you are pregnant, nursing, taking medication, or managing a health condition. Keep out of reach of children. TENDOFORTE®, TENDAXION®, and CHONDROPURE® are registered trademarks of their respective owners.