Brain Support Plus features Cerenx® brand Citicoline (CDP 5’-phosphatidyl choline)
Educational information: The content on this page is provided for general educational purposes only and is not medical advice. Statements about ingredients describe how they support normal structure and function of the body — they are not intended to diagnose, treat, cure, or prevent any disease. Consult a qualified healthcare provider before starting any new supplement.*
Omne Diem®
Brain Support Plus
Feed your brain. OmneDiem® Brain Support Plus pairs Cerenx® Citicoline (CDP 5'-phosphatidyl choline) with MecobalActive® Methylcobalamin (Vitamin B12) to support mood, mental energy, focus, attention, concentration, and mental acuity.*
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A natural source of choline for a healthy brain
At its core is the Cerenx® brand Citicoline, a natural source of choline that helps promote healthy brain structure and function — including mood, mental energy, focus, attention, concentration, and mental acuity.* Now with the addition of MecobalActive® Methylcobalamin, the bioactive, high-absorption form of Vitamin B12 and an essential brain nutrient.*
Citicoline, also known as CDP-Choline, is one of the most extensively studied nutrients for cognitive wellness, having been evaluated in hundreds of clinical trials worldwide for applications including memory, attention, focus, mood, and brain energy.1, 2*
How Citicoline supports your brain
Choline Donor
Citicoline is a choline donor for phosphatidylcholine, a phospholipid “building block” for neurons, and acetylcholine, a neurotransmitter used for neuron-to-neuron signaling, learning, and memory storage and recall.3, 4*
Antioxidant Support
Citicoline helps stimulate glutathione synthesis and the activity of the enzyme glutathione reductase. Glutathione is a powerful antioxidant that helps scavenge excess free radicals, protecting cells and tissues from oxidative stress.3, 5*
More Than Choline
Citicoline supplementation provides more than the metabolite choline — it also yields uridine, a molecule associated with brain levels of norepinephrine and dopamine, healthy mitochondrial function, and energy production in the brain.4, 5*
Healthy phosphatidylcholine and acetylcholine levels, along with balanced oxidative stress, are part of what supports the brain in maintaining normal cognitive function as we age.4*
What the research shows
Memory
In a crossover study, higher-dose citicoline supplementation was associated with improved immediate and delayed logical memory compared with placebo among older adults with relatively inefficient memory.6*
Cellular Synthesis & Brain Energy
Over six weeks, citicoline supplementation was associated with increases in markers of brain membrane formation (phosphocreatine, ~26%) and brain energy (high-energy phosphates, ~14%) compared with baseline among healthy, middle-aged adults, as measured by phosphorus magnetic resonance spectroscopy.7*
Attention & Focus
Fewer omission and commission errors on a sustained-attention task were reported with citicoline supplementation compared with placebo among healthy adult women ages 40–60.8*
Supporting cognitive wellness as you age
Maintaining everyday cognitive function — memory, alertness, and focus — is one of the most common wellness goals among health-conscious adults. Many people notice that staying sharp takes a little more support in their 50s and beyond, which is why a daily brain-nutrition routine built around a well-researched ingredient like Cerenx® Citicoline can be a simple, proactive choice.*
A note on aging: normal, everyday changes in memory and focus are a natural part of getting older. Brain Support Plus is intended to provide daily nutritional support for healthy brain function — it is not intended to diagnose, treat, cure, or prevent any disease or medical condition.*
Clean formula
Does not contain: wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, or artificial preservatives.
Support your memory, focus, and mental clarity daily
Cognitive-support nutrients work best with consistent daily use. Choose a one-time purchase or Subscribe & Save.*
FAQ
What is Citicoline (CDP-Choline)?
Citicoline, also called CDP-Choline, is a natural source of choline and one of the most well-researched nutrients for supporting cognitive wellness, including memory, focus, attention, and brain energy.*
What is Cerenx®?
Cerenx® is a branded, high-quality form of citicoline. Brain Support Plus pairs it with MecobalActive® methylcobalamin (the bioactive form of Vitamin B12) for daily cognitive support.*
How is methylcobalamin different than regular B12?
Methylcobalamin is the bioactive, preferred high-absorption form of Vitamin B12, an essential brain nutrient.*
How long does it take Brain Support Plus to start working?
Cognitive-support nutrients work best with consistent daily use over time. Individual results vary; use as directed and consult your healthcare provider with questions specific to you.
References
- Synoradzki K, Grieb P. Citicoline: A Superior Form of Choline? Nutrients. 2019. Review of citicoline clinical research. Link
- Jasielski P, et al. Application of Citicoline in Neurological Disorders: A Systematic Review. Nutrients. 2020. Link
- Secades JJ, Lorenzo JL. Citicoline: pharmacological and clinical review. Methods Find Exp Clin Pharmacol. 2006.
- Grieb P. Neuroprotective properties of citicoline: facts, doubts and unresolved issues. CNS Drugs. 2014. Link
- Wignall ND, Brown ES. Citicoline mechanism review. Natural Medicine Journal / ScienceDirect Topics: Citicoline overview. Link
- Spiers PA, et al. Citicoline improves verbal memory in aging. Arch Neurol. 1996;53(5):441-448. Link
- Silveri MM, et al. Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. NMR Biomed. 2008;21(10):1066-1075. Link
- McGlade E, et al. Improved Attentional Performance Following Citicoline Administration in Healthy Adult Women. Food and Nutrition Sciences. 2012;3:769-773. Link
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. This information is for general educational purposes only and is not a substitute for professional medical advice. Consult a qualified healthcare provider before beginning any new supplement, especially if you are pregnant, nursing, taking medication, or managing a health condition. Individual results may vary. Keep out of reach of children.