About Us
DAO Enzyme Support for Histamine Intolerance
Histamine Digest® supplies diamine oxidase (DAO) — the enzyme that breaks down histamine in your digestive tract — so you can eat the foods you love with more confidence.*
A New Kind of Company for a New Kind of Healthcare
OmneDiem® is headquartered in Ann Arbor, Michigan, where we develop clinically informed dietary supplements that address under-served and emerging health needs — the concerns mainstream supplement brands overlook.
Through a multi-channel approach, we serve consumers, healthcare practitioners, distributors, and retailers alike, advancing integrative wellness with formulas built for specific, real-world indications rather than one-size-fits-all wellness. Our primary focus is digestive health and food intolerances, where we are the recognized U.S. leader in histamine intolerance (HIT).
What Is Histamine Intolerance (HIT)?
Histamine intolerance happens when your body can't break down histamine fast enough — usually because of low diamine oxidase (DAO), the enzyme that clears histamine in the gut.
When dietary histamine builds up faster than your DAO can process it, the result can be digestive discomfort and sensitivity reactions after eating high-histamine foods like aged cheese, wine, fermented foods, and cured meats.*
Histamine itself is a natural biogenic amine found throughout the body and the food supply. Aging, fermentation, and food processing all raise the histamine load in everyday foods and beverages — which is exactly where DAO support can help.*
How OmneDiem® Solves It
Take Histamine Digest® before high-histamine meals to supplement the DAO enzyme your body may be missing.
Histamine Digest® delivers diamine oxidase (DAO) to help neutralize histamine in the digestive tract, helping defend against histamine sensitivity and the reactions that come with it.*
We pioneered this category. Our work in HIT began in 2000 with extensive clinical research. In 2016, OmneDiem® launched as the first U.S. company to offer DAOgest®, a natural diamine oxidase enzyme, as a dedicated supplement for managing histamine intolerance — paired with a nationwide education campaign. We continue to reinvest in clinical research, education, and product improvements, and the Histamine Digest® product line remains the most effective HIT support available in the U.S.
Why Choose OmneDiem®
Category Pioneer
The first U.S. brand dedicated to histamine intolerance, with research dating to 2000.
Clinically Informed
Pharmaceutical-grade formulas designed for specific indications, not generic wellness.
Made for Real Needs
Focused on underserved concerns like HIT, DAO deficiency, and food intolerance.
Trusted Nationwide
Sold to consumers, clinicians, distributors, and retailers across the U.S.
Satisfaction Guarantee
100% money-back guarantee on your first purchase — one bottle, within 30 days.**
Frequently Asked Questions
What does DAO (diamine oxidase) do?
DAO is the primary enzyme that breaks down histamine in your digestive tract. When DAO activity is low, dietary histamine can accumulate and trigger sensitivity reactions.*
What is DAO deficiency?
DAO deficiency means your body produces too little diamine oxidase to keep up with the histamine in your diet. It's a leading cause of histamine intolerance and can be supported by supplementing DAO before meals.*
When should I take Histamine Digest®?
Take Histamine Digest® shortly before consuming high-histamine foods and beverages, so the DAO enzyme is present in your digestive tract as you eat.*
Is Histamine Digest® a medication or an antihistamine?
No. Histamine Digest® is a dietary supplement that supplies the DAO enzyme to support histamine breakdown in digestion. It is not a drug and does not block histamine receptors the way oral antihistamines do.*
Which Histamine Digest® product is right for me?
Most people start with Histamine Digest® with DAO (60 capsules). Those with higher needs or multiple sensitivities may prefer Histamine Digest® PureMAX (40,000 HDU) or Histamine Digest® 360, which adds activated B6 (P5P).*
Where is OmneDiem® based?
OmneDiem® is headquartered in Ann Arbor, Michigan, and ships across the U.S. and U.S. territories.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
**100% guarantee applies to your first purchase; return one bottle within 30 days of receipt for a complete refund.