How does Menopause effect your normal DAO production?

Estrogen influences the body's natural Diamine Oxidase (DAO) enzyme activity. As estrogen fluctuates and declines during perimenopause and menopause, DAO activity may be affected, which means the body may process histamine from food and beverages differently than it once did. Many women notice this as a new sensitivity to wine, aged cheeses, fermented foods, or other high-histamine items they previously enjoyed without issue. Supporting healthy DAO activity with a dietary supplement may help support histamine comfort during this transition.

Estrogen Fluctuations and DAO Activity

Estrogen is known to stimulate mast cells, which play a role in histamine release in the body. Research suggests that estrogen may also influence DAO enzyme regulation. While overall estrogen declines during menopause, erratic fluctuations and periods of relative estrogen dominance may affect the body's capacity to support healthy histamine clearance — and DAO activity along with it.* This is not a disease or disorder. It is a natural hormonal change that many women experience during this season of life.

Progesterone and Mast Cell Activity

Progesterone is understood to support a calming effect on mast cells, which are involved in histamine release. As progesterone declines during perimenopause and menopause, mast cell activity may become less regulated, potentially contributing to changes in how histamine is experienced — while DAO activity may simultaneously be affected by the hormonal environment.*

Gut Health and DAO Synthesis

A significant portion of the body's DAO is produced in the gut lining. Menopause is associated with changes in gut motility and the gut microbiome, and gut inflammation may further affect the body's natural capacity to synthesize and utilize DAO.* Supporting overall gut health during this transition may be an important part of supporting healthy DAO activity.*

Supporting your body's natural DAO activity through targeted dietary supplementation may be one way to help support histamine comfort during and after the menopausal transition.* OmneDiem® offers a full family of Histamine Digest® DAO enzyme supplements, as well as Menopause Complete®— a daily capsule that combines DAO with phytoestrogens, black cohosh, flaxseed lignans, and citicoline to support women through this transition comprehensively.*

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.